Alkene stability (And Instability) What factors influence alkene stability? If you’ve studied elimination reactions, no doubt you’ve learned about Zaitsev’s dominance – around how remove reactions usually favor the “more substituted” alkene.

In this article we check out how raising substitution at carbon rises the stability of alkenes, as well as the results of conjugation and strain.

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At ring size of 11 and also 12 the trans-isomer actually becomes more stable (when enabled to equilibrate v acid) yet recall the anything involving equilibrium is at some point a measure up of delta G, and delta G also includes one entropy term (S). It turns out the the main factor in the raised stability of 11- and also 12- membered trans-cycloalkenes is their greater entropy. See this reference.